Opening new paths in aging research
DeepMind Blog · 2026-05-16
Calico Life Sciences researchers are using Google DeepMind's Co-Scientist multi-agent AI to generate and refine novel hypotheses about the integrated stress response in aging, producing new findings on ISR-metabolism regulation that the team plans to publish.
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Extraction
Topics: co-scientistaging-researchai-for-scienceintegrated-stress-responsebiology
Claims
- Co-Scientist helped Calico researchers generate a novel hypothesis linking integrated stress response (ISR) regulation to metabolism, a pathway known to change with age.
- Experiments guided by Co-Scientist produced new findings with important implications for ISR's role in health and disease, with a publication planned.
- Co-Scientist demonstrated scientific discernment by filtering low-quality and non-replicating findings in the aging biology literature.
- Calico researchers used Co-Scientist interactively throughout the experimental cycle, refining designs and incorporating emerging results in real time.
Key quotes
Onsum says Co-Scientist impressed Calico's experts with its scientific discernment, helping cut through that noise to help them identify new ideas genuinely worth exploring.
The Calico team used Co-Scientist to generate a novel yet plausible hypothesis about how the ISR is regulated by metabolism, which is known to change with age and in various diseases.